Posts Tagged ‘Dronedarone’

It isn’t working

April 11, 2010

Durn it!

Dronedarone, the Atrial Fibrillation drug that has been highlighted here before, isn’t living up to the hype. It was already known that it is not as effective as Amiodarone, but it doesn’t have the side effects that drug has. The hope was that if you developed A-Fib at an early age, or have a milder form of A-Fib, you could be switched from Amiodarone to Dronedarone. Amiodarone is an effective suppressor of A-Fib but the side effects can be terrible.

In fact, the last time I wrote about Amiodarone, I was accused of using “scare tactics” to get my point across. I wouldn’t do that – Heart Defects are  scary things; As any parent/CHDer knows. I’m not going to add to the hysteria. Behind every link on this blog is more information about a subject; click and read for yourself. HERE is the link I used the last time, it’s written by a Cardiologist. Obviously, he knows more about this drug than I do, and he isn’t a fan of Amiodarone, either.

Further testing has shown that Dronedarone is only half as effective in humans and doubles the rate of death! Dronedarone is recommended only as a second or third choice for people who can’t tolerate Amiodarone. Britain’s National Institute for Health and Clinical Excellence (NICE) gave the drug its approval after originally turning it down, based on its limited effectiveness and its price.

So while Dronedarone doesn’t look like it can be the answer everyone was looking for, perhaps it does have a place in the “medical toolbox”. For right now, the first drug of choice is still Amiodarone, and Cardiac Ablation is still an option.

And other researchers will continue to search for better answers.

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Flip the Switch

March 15, 2010

Nobody likes Amiodarone, not even the doctors who prescribe it. I recently wrote a post about it and all the side effects it can cause. A newer drug, Dronedarone, is usually recommended for younger patients. The longer you are on Amiodarone, the better the chances that the side effects will show. Dronedarone isn’t as effective as Amiodrone in controlling Atrial Fibrillation, but has less side effects.

New research released today at the ACC10 meeting in Atlanta shows that in two seperate trial studies, patients with controlled Atrial Fibrilation can safely switch from Amiodarone to Dronedarone in as little as two days.  If you have a slow heart rate (Bradyarrhythmia) or a long QT interval, the 48 hour guideline probably isn’t the best therapy for you. Your own cardiologist will be your best source of information.